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KMID : 0869620040210010012
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Journal of Korean Society of Hospital Pharmacists
2004 Volume.21 No. 1 p.12 ~ p.22
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Quality of Life Study of a Combination of Capecitabine and Cisplatin versus Fluorouracil and Cisplatin in patient with Advanced Gastric Cancer
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Yoo Hee-Won
Shin Eun-Jeong
Lee Kwang-Ja
Han Hyun-Joo
Son In-Ja
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Abstract
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The improvement of medical treatment and anticancer drug has led a complete recovery and prolonged survival time of cancer patients. And recent study of cancer has included evaluation of quality of life. This study was performed to evaluate quality of life between Capecitabine/Cisplatin arm and Fluorouracil/Cisplatin arm. This study was performed in the Seoul National University Hospital from August to October 2003. A total of 8 AGC patients on adjuvant chemotherapy successfully completed this study. Method of study is questionnairing by EORTC QLQ-C30, cancer specific questionnaire. The questionnaire consists of Functional, Symptom, Global health quality of life scale. Patients eligible for this study had histologically confirmed stage III or IV AGC. Patients were to be between 18 and 60 years old, and have performance status of 1. Patients were ineligible if they had a history of 6 months prior or concomitant chemotherapy, radiotherapy. Statistically significant differences favoring the Fluorouracil/Cisplatin arm was noted in the physical scale. In addition, patients in the Fluorouracil/Cisplatin arm reported an improvement in physical functioning after one cycle chemotherapy.
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KEYWORD
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Advanced Gastric Cancer (AGC), Quality of life (QOL), Fluorouracil, Cisplatin, Capecitabine, EORTC QLQ-C30
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